Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils.

ABSTRACT:

Background

Aspergillus fumigatus is the most common etiologic agent of invasive aspergillosis in immunocompromised patients. Several studies have addressed the mechanism involved in host defense but only few have investigated the pathogen's response to attack by the host cells. To our knowledge, this is the first study that investigates the genes differentially expressed in conidia vs hyphae of A. fumigatus in response to neutrophils from healthy donors as well as from those with chronic granulomatous disease (CGD) which are defective in the production of reactive oxygen species.

Methodology/principal findings

Transcriptional profiles of conidia and hyphae exposed to neutrophils, either from normal donors or from CGD patients, were obtained by using the genome-wide microarra

SUBMITTER: Sugui JA 

PROVIDER: S-EPMC2481287 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature