Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence.

ABSTRACT: Regional rates of recombination often correlate with levels of nucleotide diversity, and either selective or neutral hypotheses can explain this relationship. Regional recombination rates also correlate with nucleotide differences between human and chimpanzee, consistent with models where recombination is mutagenic; however, a lack of correlation is observed in the Drosophila melanogaster group, consistent with models invoking natural selection. Here, we revisit the relationship among recombination, diversity, and interspecies difference by generating empirical estimates of these parameters in Drosophila pseudoobscura. To measure recombination rate, we genotyped 1,294 backcross hybrids at 50 markers across the largest assembled linkage group in this species. Genome-wide diversity was estim

SUBMITTER: Kulathinal RJ 

PROVIDER: S-EPMC2481358 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature