Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome.

ABSTRACT:

Introduction

High mobility group box 1 protein (HMGB1) is a pleiotropic cytokine, recently implicated in the pathophysiology of the systemic inflammatory response syndrome (SIRS) and sepsis. Data from experimental sepsis models show that administration of anti-HMGB1 antibodies significantly decreased mortality, even when administration was delayed for 24 hours, providing a window of opportunity for therapeutic intervention if transferred into a clinical setting. Whether genetic variation in the human HMGB1 gene is associated with disease susceptibility is unknown.

Methods

We sequenced the HMGB1 gene in 239 prospectively monitored patients with SIRS admitted to an intensive care unit and we measured the corresponding HMGB1 serum concentrations. Blood donors served as control

SUBMITTER: Kornblit B 

PROVIDER: S-EPMC2481482 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature