Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues.

ABSTRACT: Aging is associated with functional and structural declines in many body systems, even in the absence of underlying disease. In particular, skeletal muscles experience severe declines during aging, a phenomenon termed sarcopenia. Despite the high incidence and severity of sarcopenia, little is known about contributing factors and development. Many studies focus on functional aspects of aging-related tissue decline, while structural details remain understudied. Traditional approaches for quantifying structural changes have assessed individual markers at discrete intervals. Such approaches are inadequate for the complex changes associated with aging. An alternative is to consider changes in overall morphology rather than in specific markers. We have used this approach to quantitatively track

SUBMITTER: Johnston J 

PROVIDER: S-EPMC2483734 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature