Major role for amphotericin B-flucytosine combination in severe cryptococcosis.

ABSTRACT:

Background

The Infectious Diseases Society of America published in 2000 practical guidelines for the management of cryptococcosis. However, treatment strategies have not been fully validated in the various clinical settings due to exclusion criteria during therapeutic trials. We assessed here the optimal therapeutic strategies for severe cryptococcosis using the observational prospective CryptoA/D study after analyzing routine clinical care of cryptococcosis in university or tertiary care hospitals.

Methodology/principal findings

Patients were enrolled if at least one culture grew positive with Cryptococcus neoformans. Control of sterilization was warranted 2 weeks (Wk2) and 3 months (Mo3) after antifungal therapy onset. 208 HIV-positive or -negative adult patients were anal

SUBMITTER: Dromer F 

PROVIDER: S-EPMC2483933 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature