Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

ABSTRACT:

Aims/hypothesis

Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes incidence and response to interventions in the Diabetes Prevention Program (DPP), in which a lifestyle intervention or metformin treatment was compared with placebo.

Methods

We genotyped the WFS1 SNPs rs10010131, rs752854 and rs734312 (H611R) in 3,548 DPP participants and performed Cox regression analysis using genotype, intervention and their interactions as predictors of diabetes incidence. We also evaluated the effect of these SNPs on insulin resistance and b

SUBMITTER: Florez JC 

PROVIDER: S-EPMC2483955 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature