Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder.

ABSTRACT: Traditionally, four groups of factors have been identified in the etiology of temporomandibular disorder (TMD): anatomical variation in the masticatory system; psychosocial characteristics; pain in other body regions; and demographics. Orthodontic treatment has been variously cited both as a protective and harmful factor in TMD etiology. Recently, a search has begun for a genetic influence on TMD etiology. Genetic markers can be of additional value in identifying gene-environment interactions, that is, isolating population sub-groups, defined by genotype in which environmental influences play a relatively greater or lesser etiological role. This paper reviews concepts and study design requirements for epidemiological investigations into TMD etiology. Findings are presented from a prospecti

SUBMITTER: Slade GD 

PROVIDER: S-EPMC2486446 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature