Ontology highlight
ABSTRACT:
SUBMITTER: Albee AJ
PROVIDER: S-EPMC2488304 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Albee Alison J AJ Wiese Christiane C
Molecular biology of the cell 20080528 8
Members of the transforming acidic coiled coil (TACC) protein family are emerging as important mitotic spindle assembly proteins in a variety of organisms. The molecular details of how TACC proteins function are unknown, but TACC proteins have been proposed to recruit microtubule-stabilizing proteins of the tumor overexpressed gene (TOG) family to the centrosome and to facilitate their loading onto newly emerging microtubules. Using Xenopus egg extracts and in vitro assays, we show that the Xeno ...[more]