Correlation between amino acid residues converted by RNA editing and functional residues in protein three-dimensional structures in plant organelles.

ABSTRACT:

Background

In plant organelles, specific messenger RNAs (mRNAs) are subjected to conversion editing, a process that often converts the first or second nucleotide of a codon and hence the encoded amino acid. No systematic patterns in converted sites were found on mRNAs, and the converted sites rarely encoded residues located at the active sites of proteins. The role and origin of RNA editing in plant organelles remain to be elucidated.

Results

Here we study the relationship between amino acid residues encoded by edited codons and the structural characteristics of these residues within proteins, e.g., in protein-protein interfaces, elements of secondary structure, or protein structural cores. We find that the residues encoded by edited codons are significantly biased toward in

SUBMITTER: Yura K 

PROVIDER: S-EPMC2488346 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature