Topoisomerase II inhibition involves characteristic chromosomal expression patterns.

ABSTRACT:

Background

The phenomenon of co-localization of transcriptionally upregulated genes showing similar expression levels is known across all eukaryotic genomes. We recently mapped the Aroclor 1254-regulated transcriptome back onto the genome and provided evidence for the statistically significant co-localization of regulated genes. They did, however, not always show similar expression levels, and many of the regulated genes were, in fact, repressed.

Results

In this study, we were able to reproduce this observation with microarray data stemming from 1) human hepatocytes treated with the gyrase and potential topoisomerase II inhibitor trovafloxacin, 2) human hepatocytes treated with the topoisomerase II inhibitor doxorubicin and 3) mouse lymphoma cells treated with the topoisomer

SUBMITTER: Reymann S 

PROVIDER: S-EPMC2488358 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature