Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion.

ABSTRACT: Francisella tularensis is a gram-negative facultative bacterium that causes the disease tularemia, even upon exposure to low numbers of bacteria. One critical characteristic of Francisella is its ability to dampen or subvert the host immune response. In order to help understand the mechanisms by which this occurs, we performed Affymetrix microarray analysis on transcripts from blood monocytes infected with the virulent Type A Schu S4 strain. Results showed that expression of several host response genes were reduced such as those associated with interferon signaling, Toll-like receptor signaling, autophagy and phagocytosis. When compared to microarrays from monocytes infected with the less virulent F. tularensis subsp. novicida, we found qualitative differences and also a general pattern of

SUBMITTER: Butchar JP 

PROVIDER: S-EPMC2488368 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature