An RBP4 promoter polymorphism increases risk of type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. The RBP4 -803GA promoter polymorphism influences binding of hepatic nuclear factor 1alpha and is associated with type 2 diabetes in case-control studies. We hypothesised that the RBP4 -803GA polymorphism increases type 2 diabetes risk at a population-based level. In addition, information on retinol intake and plasma vitamin A levels enabled us to explore the possible underlying mechanism.

Methods

In the Rotterdam Study, a prospective, population-based, follow-up study, the -803GA polymorphism was genotyped. In Cox proportional hazards models, associations of the -803GA polymorphism and retinol intake with type 2 diabe

SUBMITTER: van Hoek M 

PROVIDER: S-EPMC2491414 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature