The role of DNA-binding specificity in the evolution of bacterial regulatory networks.

ABSTRACT: Understanding the mechanisms by which transcriptional regulatory networks (TRNs) change through evolution is a fundamental problem.Here, we analyze this question using data from Escherichia coli and Bacillus subtilis, and find that paralogy relationships are insufficient to explain the global or local role observed for transcription factors (TFs) within regulatory networks. Our results provide a picture in which DNA-binding specificity, a molecular property that can be measured in different ways, is a predictor of the role of transcription factors. In particular, we observe that global regulators consistently display low levels of binding specificity, while displaying comparatively higher expression values in microarray experiments. In addition, we find a strong negative correlation betwee

SUBMITTER: Lozada-Chavez I 

PROVIDER: S-EPMC2491489 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature