Timing and deciphering mitochondrial DNA macro-haplogroup R0 variability in Central Europe and Middle East.

ABSTRACT:

Background

Nearly half of the West Eurasian assemblage of human mitochondrial DNA (mtDNA) is fractioned into numerous sub-lineages of the predominant haplogroup (hg) R0. Several hypotheses have been proposed on the origin and the expansion times of some R0 sub-lineages, which were partially inconsistent with each other. Here we describe the phylogenetic structure and genetic variety of hg R0 in five European populations and one population from the Middle East.

Results

Our analysis of 1,350 mtDNA haplotypes belonging to R0, including entire control region sequences and 45 single nucleotide polymorphisms from the coding region, revealed significant differences in the distribution of different sub-hgs even between geographically closely located regions. Estimates of coalescence

SUBMITTER: Brandstatter A 

PROVIDER: S-EPMC2491632 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature