Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis.

ABSTRACT:

Background

A reciprocal relationship between bone and fat development in osteoporosis is clinically well established. Some of the key molecular regulators involved in this tissue replacement process have been identified. The detailed mechanisms governing the differentiation of mesenchymal stem cells (MSC) - the key cells involved - are however only now beginning to emerge. In an attempt to address the regulation of the adipocyte/osteoblast balance at the level of gene transcription in a comprehensive and unbiased manner, we performed a large-scale gene expression profiling study using a unique cellular model, human multipotent adipose tissue-derived stem cells (hMADS).

Results

The analysis of 1606 genes that were found to be differentially expressed between adipogenesis and

SUBMITTER: Scheideler M 

PROVIDER: S-EPMC2492879 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature