Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers.

ABSTRACT:

Aims

To investigate the interaction between ketoconazole and darunavir (alone and in combination with low-dose ritonavir), in HIV-healthy volunteers.

Methods

Volunteers received darunavir 400 mg bid and darunavir 400 mg bid plus ketoconazole 200 mg bid, in two sessions (Panel 1), or darunavir/ritonavir 400/100 mg bid, ketoconazole 200 mg bid and darunavir/ritonavir 400/100 mg bid plus ketoconazole 200 mg bid, over three sessions (Panel 2). Treatments were administered with food for 6 days. Steady-state pharmacokinetics following the morning dose on day 7 were compared between treatments. Short-term safety and tolerability were assessed.

Results

Based on least square means ratios (90% confidence intervals), during darunavir and ketoconazole co-administration, darunavir

SUBMITTER: Sekar VJ 

PROVIDER: S-EPMC2492919 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature