Dynamic transcriptomic response to acute hypertension in the nucleus tractus solitarius.

ABSTRACT: Baroreceptor afferents project to the cardiovascular region of the nucleus tractus solitarius (cvNTS), and their cvNTS target neurons may play a role in governing the sensitivity and operating range of the arterial baroreceptor reflex (baroreflexes). Recent studies have shown differential gene and protein expression in the cvNTS in response to changed arterial pressure. However, the extent of these responses is unknown. Therefore, we collected differential global gene expression data in a time series following acute hypertension in awake, freely moving rats. To acquire statistically significant results and place them in functional context, we overcame several quality control requirements and developed novel analytical approaches. The physiologically new findings from the study are that acu

SUBMITTER: Khan RL 

PROVIDER: S-EPMC2494808 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature