A periodic pattern generator for dental diversity.

ABSTRACT:

Background

Periodic patterning of iterative structures is a fundamental process during embryonic organization and development. Studies have shown how gene networks are employed to pattern butterfly eyespots, fly bristles and vertebrate epithelial appendages such as teeth, feathers, hair and mammary glands. Despite knowledge of how these features are organized, little is known about how diversity in periodic patterning is generated in nature. We address this problem through the molecular analysis of oral jaw dental diversity in Lake Malawi cichlids, where closely related species exhibit from 1 to 20 rows of teeth, with total teeth counts ranging from around 10 to 700.

Results

We investigate the expression of conserved gene networks (involving bmp2, bmp4, eda, edar, fgf8, pax9

SUBMITTER: Fraser GJ 

PROVIDER: S-EPMC2496899 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature