Laminin enhances the growth of human neural stem cells in defined culture media.

ABSTRACT:

Background

Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As such, it is important to identify factors which enhance the growth of hNSC. In vivo, stem cells reside in distinct microenvironments or niches that are responsible for the maintenance of stem cell populations. A common feature of niches is the presence of the extracellular matrix molecule, laminin. Therefore, this study investigated the effect of exogenous laminin on hNSC growth.

Results

To measure hNSC growth, we established culture conditions using B27-supplemen

SUBMITTER: Hall PE 

PROVIDER: S-EPMC2496909 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature