Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

ABSTRACT:

Background

Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models.

Methodology/principal findings

We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congenic strain of the spontaneously diabetic Goto-Kakizaki (GK) rat containing a large region (110 cM, 170 Mb) of rat chromosome 1 (RNO1), which covers diabetes and obesity quantitative trait loci (QTL), introgressed onto the genetic background of the normoglycaemic Brown Norway (BN) strain. This novel disease model, which by the length of the congenic region closely mirrors the situation of a chromosome substitution strain, exhibits a wide range of abnormalities directly relevant to comp

SUBMITTER: Wallis RH 

PROVIDER: S-EPMC2500170 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature