Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.

ABSTRACT:

Background

Genome-wide association (GWA) studies identified a series of novel type 2 diabetes risk loci. Most of them were subsequently demonstrated to affect insulin secretion of pancreatic beta-cells. Very recently, a meta-analysis of GWA data revealed nine additional risk loci with still undefined roles in the pathogenesis of type 2 diabetes. Using our thoroughly phenotyped cohort of subjects at an increased risk for type 2 diabetes, we assessed the association of the nine latest genetic variants with the predominant prediabetes traits, i.e., obesity, impaired insulin secretion, and insulin resistance.

Methodology/principal findings

One thousand five hundred and seventy-eight metabolically characterized non-diabetic German subjects were genotyped for the reported candidat

SUBMITTER: Staiger H 

PROVIDER: S-EPMC2500187 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature