Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event.

ABSTRACT: Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological markers that accurately predict conversion of CIS to clinically definite MS (CDMS). Furthermore, the earliest molecular events in MS are still unknown. We used microarrays to study gene expression in naïve CD4(+) T cells from 37 CIS patients at time of diagnosis and after 1 year. Supervised machine-learning methods were used to build predictive models of disease conversion. We identified 975 genes whose expression segregated CIS patients into four distinct subgroups. A subset of 108 genes further discriminated patients in one of these (group 1) from other CIS patients. Remarkably, 92% of patients in group 1 converted to CDMS within 9 mont

SUBMITTER: Corvol JC 

PROVIDER: S-EPMC2504481 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature