Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy.

ABSTRACT:

Background

Despite guidelines establishing the need to perform comprehensive paediatric drug development programs, pivotal trials in children with epilepsy have been completed mostly in Phase IV as a postapproval replication of adult data. However, it has been shown that the treatment response in children can differ from that in adults. It has not been investigated whether differences in drug effect between adults and children might occur in the treatment of drug-resistant partial epilepsy, although such differences may have a substantial impact on the design and results of paediatric randomised controlled trials (RCTs).

Methods and findings

Three electronic databases were searched for RCTs investigating any antiepileptic drug (AED) in the add-on treatment of drug-resistant

SUBMITTER: Rheims S 

PROVIDER: S-EPMC2504483 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature