Turn-on and ratiometric mercury sensing in water with a red-emitting probe.

ABSTRACT: The synthesis, photophysical properties, and Hg(II) binding of a red-emitting sensor for mercuric ion are presented. 2-[11-[(2-[[Bis-(2-ethylsulfanylethyl)amino]methyl]phenylamino)methyl]-3-hydroxy-10-oxo-10H-benzo[c]xanthen-7-yl]benzoic acid (MS5) is based on the seminaphthofluorescein chromophore and employs a thioether-rich metal-binding unit. This sensor affords both turn-on and single-excitation dual-emission ratiometric Hg(II) detection in aqueous solution. The fluorescence response of MS5 is Hg(II)-specific, and the probe is selective for Hg(II) over alkali and alkaline earth metals, most divalent first-row transition metal ions, and the Group 12 congeners Zn(II) and Cd(II). MS5 binds Hg(II) reversibly and can be recycled. The EC50 for 1 microM MS5 is 910 nM, and a lower detection l

SUBMITTER: Nolan EM 

PROVIDER: S-EPMC2505192 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature