[18F]2-fluoro-2-deoxy-D-glucose positron emission tomography demonstration of estrogen negative and positive feedback on luteinizing hormone secretion in women.

ABSTRACT:

Context

Precise regulation of the neuroendocrine components of the female reproductive axis involves both negative and positive feedback of estrogen on gonadotropin secretion.

Objective

Our objective was to determine the hypothalamic and/or pituitary sites of estrogen negative and positive feedback using neuroimaging techniques.

Design and setting

A graded estrogen infusion protocol was administered at a General Clinical Research Center in an academic medical center.

Subjects

Healthy postmenopausal women (n = 11) were recruited for study.

Interventions

Serum samples were measured every 4 h. A structural magnetic resonance imaging was performed at baseline, and [(18)F]2-fluoro-2-deoxy-d-glucose ((18)FDG) positron emission tomography was performed at basel

SUBMITTER: Ottowitz WE 

PROVIDER: S-EPMC2515077 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature