Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection.

ABSTRACT:

Background

The molecular events and evolutionary forces underlying lethal mutagenesis of virus (or virus extinction through an excess of mutations) are not well understood. Here we apply for the first time phylogenetic methods and Partition Analysis of Quasispecies (PAQ) to monitor genetic distances and intra-population structures of mutant spectra of foot-and-mouth disease virus (FMDV) quasispecies subjected to mutagenesis by base and nucleoside analogues.

Results

Phylogenetic and PAQ analyses have revealed a highly dynamic variation of intrapopulation diversity of FMDV quasispecies. The population diversity first suffers striking expansions in the presence of mutagens and then compressions either when the presence of the mutagenic analogue was discontinued or when a mutati

SUBMITTER: Ojosnegros S 

PROVIDER: S-EPMC2515104 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature