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A virtual look at Epstein-Barr virus infection: simulation mechanism.


ABSTRACT: Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.

SUBMITTER: Shapiro M 

PROVIDER: S-EPMC2515170 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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A virtual look at Epstein-Barr virus infection: simulation mechanism.

Shapiro M M   Duca K A KA   Lee K K   Delgado-Eckert E E   Hawkins J J   Jarrah A S AS   Laubenbacher R R   Polys N F NF   Hadinoto V V   Thorley-Lawson D A DA  

Journal of theoretical biology 20080216 4


Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and re  ...[more]

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