Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.

ABSTRACT:

Background

The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date. Meta-analysis of 27 different studies has resulted in a global OR of 1.46 [1.42-1.51] (rs7903146 variant). Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established.

Methods

We performed a case-control association study using 522 Saudi T2D patients (WHO criteria), and 346 controls (age > 60; fasting plasma glucose < 7 mmol/L). Genotyping was performed by pyrosequencing. Statistical analyses were performed using SPSS version 13.0 for Windows (SPSS, Chicago, IL, USA).

Results

For rs7903146, the T allele frequency of the cases (0.415) was not different from that observed i

SUBMITTER: Alsmadi O 

PROVIDER: S-EPMC2515290 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature