A coarsened multinomial regression model for perinatal mother to child transmission of HIV.

ABSTRACT:

Background

In trials designed to estimate rates of perinatal mother to child transmission of HIV, HIV assays are scheduled at multiple points in time. Still, infection status for some infants at some time points may be unknown, particularly when interim analyses are conducted.

Methods

Logistic regression models are commonly used to estimate covariate-adjusted transmission rates, but their methods for handling missing data may be inadequate. Here we propose using coarsened multinomial regression models to estimate cumulative and conditional rates of HIV transmission. Through simulation, we compare the proposed models to standard logistic models in terms of bias, mean squared error, coverage probability, and power. We consider a range of treatment effect and visit process scen

SUBMITTER: Gard CC 

PROVIDER: S-EPMC2515333 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature