Unified total synthesis of pteriatoxins and their diastereomers.

ABSTRACT: A unified total synthesis is reported to access all of the possible diastereomers of pteriatoxins A-C, with the use of an intramolecular Diels-Alder reaction as the key step to form the carbo-macrocyclic core structure. The C34/C35-diol protecting groups were found to have significant effects on both the exo/endo-selectivity and the exo-facial selectivity of the intramolecular Diels-Alder process.

SUBMITTER: Matsuura F 

PROVIDER: S-EPMC2515931 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature