Experimental estimation of mutation rates in a wheat population with a gene genealogy approach.

ABSTRACT: Microsatellite markers are extensively used to evaluate genetic diversity in natural or experimental evolving populations. Their high degree of polymorphism reflects their high mutation rates. Estimates of the mutation rates are therefore necessary when characterizing diversity in populations. As a complement to the classical experimental designs, we propose to use experimental populations, where the initial state is entirely known and some intermediate states have been thoroughly surveyed, thus providing a short timescale estimation together with a large number of cumulated meioses. In this article, we derived four original gene genealogy-based methods to assess mutation rates with limited bias due to relevant model assumptions incorporating the initial state, the number of new alleles, a

SUBMITTER: Raquin AL 

PROVIDER: S-EPMC2516091 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature