Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus.

ABSTRACT: All classes of antidepressants increase hippocampal cell proliferation and neurogenesis, which contributes, in part, to the behavioral actions of these treatments. Among antidepressant treatments, electroconvulsive seizure (ECS) is the most robust stimulator of hippocampal cell proliferation and the most efficacious treatment for depression, but the cellular mechanisms underlying the actions of ECS are unknown. To address this question, we investigated the effect of ECS on proliferation of neural stem-like and/or progenitor cells in the subgranular zone of rat dentate gyrus. We define the neural differentiation cascade from stem-like cells to early neural progenitors (also referred to as quiescent and amplifying neural progenitors, respectively) by coexpression of selective cellular and mi

SUBMITTER: Segi-Nishida E 

PROVIDER: S-EPMC2516270 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature