Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress.

ABSTRACT: A variety of cardiovascular, neurological, and neoplastic conditions have been associated with oxidative stress, i.e., conditions under which levels of reactive oxygen species (ROS) are elevated over significant periods. Nuclear factor erythroid 2-related factor (Nrf2) regulates the transcription of several gene products involved in the protective response to oxidative stress. The transcriptional regulatory and signaling relationships linking gene products involved in the response to oxidative stress are, currently, only partially resolved. Microarray data constitute RNA abundance measures representing gene expression patterns. In some cases, these patterns can identify the molecular interactions of gene products. They can be, in effect, proxies for protein-protein and protein-DNA interact

SUBMITTER: Taylor RC 

PROVIDER: S-EPMC2516606 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature