RETRACTED: Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

ABSTRACT:

Background

Dysregulated PI3K/Akt signaling occurs commonly in breast cancers and is due to HER2 amplification, PI3K mutation or PTEN inactivation. The objective of this study was to determine the role of Akt activation in breast cancer as a function of mechanism of activation and whether inhibition of Akt signaling is a feasible approach to therapy.

Methodology/principal findings

A selective allosteric inhibitor of Akt kinase was used to interrogate a panel of breast cancer cell lines characterized for genetic lesions that activate PI3K/Akt signaling: HER2 amplification or PI3K or PTEN mutations in order to determine the biochemical and biologic consequences of inhibition of this pathway. A variety of molecular techniques and tissue culture and in vivo xenograft models revea

SUBMITTER: She QB 

PROVIDER: S-EPMC2516933 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature