Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations.

ABSTRACT: We develop a point model of the cardiac myofilament (MF) to simulate a wide variety of experimental muscle characterizations including Force-Ca relations and twitches under isometric, isosarcometric, isotonic, and auxotonic conditions. Complex MF behaviors are difficult to model because spatial interactions cannot be directly implemented as ordinary differential equations. We therefore allow phenomenological approximations with careful consideration to the relationships with the underlying biophysical mechanisms. We describe new formulations that avoid mean-field approximations found in most existing MF models. To increase the scope and applicability of the model, we include length- and temperature-dependent effects that play important roles in MF responses. We have also included a represe

SUBMITTER: Rice JJ 

PROVIDER: S-EPMC2517033 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature