Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum.

ABSTRACT: The central dogma of radiation biology, that biological effects of ionizing radiation are a direct consequence of DNA damage occurring in irradiated cells, has been challenged by observations that genetic/epigenetic changes occur in unexposed "bystander cells" neighboring directly-hit cells, due to cell-to-cell communication or soluble factors released by irradiated cells. To date, the vast majority of these effects are described in cell-culture systems, while in vivo validation and assessment of biological consequences within an organism remain uncertain. Here, we describe the neonatal mouse cerebellum as an accurate in vivo model to detect, quantify, and mechanistically dissect radiation-bystander responses. DNA double-strand breaks and apoptotic cell death were induced in bystander cere

SUBMITTER: Mancuso M 

PROVIDER: S-EPMC2517601 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature