Protein complex evolution does not involve extensive network rewiring.

ABSTRACT: The formation of proteins into stable protein complexes plays a fundamental role in the operation of the cell. The study of the degree of evolutionary conservation of protein complexes between species and the evolution of protein-protein interactions has been hampered by lack of comprehensive coverage of the high-throughput (HTP) technologies that measure the interactome. We show that new high-throughput datasets on protein co-purification in yeast have a substantially lower false negative rate than previous datasets when compared to known complexes. These datasets are therefore more suitable to estimate the conservation of protein complex membership than hitherto possible. We perform comparative genomics between curated protein complexes from human and the HTP data in Saccharomyces cerevi

SUBMITTER: van Dam TJ 

PROVIDER: S-EPMC2517612 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature