Ontology highlight
ABSTRACT:
SUBMITTER: Wolf D
PROVIDER: S-EPMC2518094 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Wolf Daniel D Hug Kevin K Goff Stephen P SP
Proceedings of the National Academy of Sciences of the United States of America 20080819 34
Murine leukemia viruses (MLVs) and related retroelements are potently restricted in embryonic cells by postintegration transcriptional silencing, likely to protect the germ line from insertional mutagenesis. This silencing is in large part attributable to the presence of a nuclear repression complex, which targets a sequence element of the proviral DNA, the repressor-binding site. The repressor-binding site closely overlaps the tRNA primer binding site, a highly conserved sequence essential for ...[more]