Altered expression of cell cycle and apoptotic proteins in chronic hepatitis C virus infection.

ABSTRACT:

Background

A disrupted cell cycle progression of hepatocytes was reported in chronic hepatitis C virus (HCV) infection, which can contribute significantly in the associated pathogenesis. The present study aimed to further elaborate these disruptions by evaluating the expression of key cell cycle and apoptotic proteins in chronic HCV infection with particular reference to genotype 3. Archival liver biopsy specimens of chronic HCV-infection (n = 46) and normal histology (n = 5) were analyzed by immunohistochemistry using antibodies against proliferation marker Mcm-2, G1 phase marker Cyclin D1, S phase marker Cyclin A, cell cycle regulators p21 (CDK inhibitor) and p53 (tumor suppressor protein), apoptotic protein Caspase-3 and anti-apoptotic protein Bcl-2.

Results

Elevated Mcm-

SUBMITTER: Sarfraz S 

PROVIDER: S-EPMC2518161 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature