Gene Ontology term overlap as a measure of gene functional similarity.

ABSTRACT:

Background

The availability of various high-throughput experimental and computational methods allows biologists to rapidly infer functional relationships between genes. It is often necessary to evaluate these predictions computationally, a task that requires a reference database for functional relatedness. One such reference is the Gene Ontology (GO). A number of groups have suggested that the semantic similarity of the GO annotations of genes can serve as a proxy for functional relatedness. Here we evaluate a simple measure of semantic similarity, term overlap (TO).

Results

We computed the TO for randomly selected gene pairs from the mouse genome. For comparison, we implemented six previously reported semantic similarity measures that share the feature of using computation

SUBMITTER: Mistry M 

PROVIDER: S-EPMC2518162 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature