Insights into protein-DNA interactions through structure network analysis.

ABSTRACT: Protein-DNA interactions are crucial for many cellular processes. Now with the increased availability of structures of protein-DNA complexes, gaining deeper insights into the nature of protein-DNA interactions has become possible. Earlier, investigations have characterized the interface properties by considering pairwise interactions. However, the information communicated along the interfaces is rarely a pairwise phenomenon, and we feel that a global picture can be obtained by considering a protein-DNA complex as a network of noncovalently interacting systems. Furthermore, most of the earlier investigations have been carried out from the protein point of view (protein-centric), and the present network approach aims to combine both the protein-centric and the DNA-centric points of view. Par

SUBMITTER: Sathyapriya R 

PROVIDER: S-EPMC2518215 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature