Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.

ABSTRACT:

Objective

Experimental infection of rats with human adenovirus type 36 (Ad-36) promotes adipogenesis and improves insulin sensitivity in a manner reminiscent of the pharmacologic effect of thiozolinediones. To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue.

Research design and methods

We determined whether Ad-36 increases glucose uptake in human adipose tissue explants. Cell-signaling pathways targeted by Ad-36 to increase glucose uptake were determined in the explants and human adipose-derived stem cells. Ad-2, a nonadipogenic human adenovirus, was used as a negative control. As a proof of concept, nondiabetic a

SUBMITTER: Rogers PM 

PROVIDER: S-EPMC2518483 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature