Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells.

ABSTRACT:

Objective

Vascular progenitors of bone marrow origin participate to neovascularization at sites of wound healing and transplantation. We hypothesized that the biological purpose of this bone marrow-derived vascular component is to contribute angiogenic and survival functions distinct from those provided by the local tissue-derived vasculature.

Research design and methods and results

To address this hypothesis, we investigated the functional impact of bone marrow-derived vascular cells on pancreatic islets engraftment using bone marrow-reconstituted Id1(+/-)Id3(-/-) mice, a model of bone marrow-derived vasculogenesis. We show that, in this model, bone marrow-derived vasculogenic cells primarily contribute to the formation of new blood vessels within islet transplants. In cont

SUBMITTER: Miller R 

PROVIDER: S-EPMC2518491 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature