Design and synthesis of a cell-permeable synthetic transcription factor mimic.

ABSTRACT: Synthetic molecules capable of activating the expression of specific genes are of great interest as tools for biological research and, potentially, as a novel class of pharmaceutical agents. It has been demonstrated previously that such synthetic transcription factor mimics (STFMs) can be constructed by connecting a sequence-specific DNA-binding module to a molecule capable of binding to the transcriptional machinery via a suitable linker. These chimeras mimic the two basic properties of native transcription factors, which are able to recognize a promoter sequence specifically and to recruit the transcriptional machinery to that promoter. However, none of the compounds of this type reported to date have been shown to function in living cells. We report here the first example of a cell-perm

SUBMITTER: Xiao X 

PROVIDER: S-EPMC2518654 | biostudies-literature | 2007 Jul-Aug

REPOSITORIES: biostudies-literature