Association of chromosome 9p21 SNPs with cardiovascular phenotypes in morbid obesity using electronic health record data.

ABSTRACT: Genomic medicine research requires substantial time and resources to obtain phenotype data. The electronic health record offers potential efficiencies in addressing these temporal and economic challenges, but few studies have explored the feasibility of using such data for genetics research. The main objective of this study was to determine the association of two genetic variants located on chromosome 9p21 conferring susceptibility to coronary heart disease and type 2 diabetes with a variety of clinical phenotypes derived from the electronic health record in a population of morbidly obese patients. Data on more than 100 clinical measures including diagnoses, laboratory values, and medications were extracted from the electronic health records of a total of 709 morbidly obese (body mass inde

SUBMITTER: Wood GC 

PROVIDER: S-EPMC2518660 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature