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Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

ABSTRACT: Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFalpha stimulation. In cells from TRADD-deficient mice, TNFalpha-mediated apoptosis and TNFalpha-stimulated NF-kappaB, JNK, and ERK activation are defective. TRADD is also important for germinal center formation, DR3-mediated costimulation of T cells, and TNFalpha-mediated inflammatory responses in vivo. TRADD deficiency does not enhance IFNgamma-induced signaling. Importantly, TRADD has a novel role in TLR3 and TLR4 signaling. TRADD participates in the TLR4 complex formed upon LPS stimulation, and TRADD-deficient macrophages show impaired cytokine production in response to TLR ligands in vitro. Thus, TRADD is a multifunctional protein crucial both for TNFR1 signaling and other signaling pathways relevant to immune responses.

SUBMITTER: Chen NJ 

PROVIDER: S-EPMC2518828 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

Chen Nien-Jung NJ   Chio Iok In Christine II   Lin Wen-Jye WJ   Duncan Gordon G   Chau Hien H   Katz David D   Huang Huey-Lan HL   Pike Kelly A KA   Hao Zhenyue Z   Su Yu-Wen YW   Yamamoto Kazuo K   de Pooter Renée F RF   Zúñiga-Pflücker Juan Carlos JC   Wakeham Andrew A   Yeh Wen-Chen WC   Mak Tak W TW  

Proceedings of the National Academy of Sciences of the United States of America 20080821 34

Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFalpha stimulation. In cells from TRADD-deficient mice, TNFalpha-mediated apoptosis and TNFalpha-stimulated NF-kappaB, JNK, and ERK activation are defective. TRADD is also important for germinal center formation, DR3-mediated costimulation of T cells, and TNFalpha-mediated inflammatory responses in vivo. TRADD deficiency does not enhance IFNgamma-induced signali  ...[more]

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