Top-down analysis of temporal hierarchy in biochemical reaction networks.

ABSTRACT: The study of dynamic functions of large-scale biological networks has intensified in recent years. A critical component in developing an understanding of such dynamics involves the study of their hierarchical organization. We investigate the temporal hierarchy in biochemical reaction networks focusing on: (1) the elucidation of the existence of "pools" (i.e., aggregate variables) formed from component concentrations and (2) the determination of their composition and interactions over different time scales. To date the identification of such pools without prior knowledge of their composition has been a challenge. A new approach is developed for the algorithmic identification of pool formation using correlations between elements of the modal matrix that correspond to a pair of concentrations

SUBMITTER: Jamshidi N 

PROVIDER: S-EPMC2518853 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature