Non-invasive cardiac assessment in high risk patients (The GROUND study): rationale, objectives and design of a multi-center randomized controlled clinical trial.

ABSTRACT:

Background

Peripheral arterial disease (PAD) is a common disease associated with a considerably increased risk of future cardiovascular events and most of these patients will die from coronary artery disease (CAD). Screening for silent CAD has become an option with recent non-invasive developments in CT (computed tomography)-angiography and MR (magnetic resonance) stress testing. Screening in combination with more aggressive treatment may improve prognosis. Therefore we propose to study whether a cardiac imaging algorithm, using non-invasive imaging techniques followed by treatment will reduce the risk of cardiovascular disease in PAD patients free from cardiac symptoms.

Design

The GROUND study is designed as a prospective, multi-center, randomized clinical trial. Patients w

SUBMITTER: de Vos AM 

PROVIDER: S-EPMC2519056 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature