Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissue.

ABSTRACT: It is known that organic forms of selenium inhibit chemically induced rat mammary carcinogenesis, although the molecular basis remains to be elucidated. To identify signaling pathways involved in carcinogenesis that are also modulated by methylselenocysteine, we compared the global gene expression profiles in mammary tissues from pubescent female rats maintained on a selenium-supplemented (3 ppm) diet with those on a standardized diet after N-nitroso-N-methylurea. Whereas the selenium-enriched diet altered the steady-state levels of genes involved in various cellular functions, the most dramatic effect was the coordinated changes in the expression of multiple genes that regulate circadian rhythm. Normal mammary tissue of rats fed a standardized diet showed little circadian oscillation rela

SUBMITTER: Zhang X 

PROVIDER: S-EPMC2519612 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature