SSD1 is integral to host defense peptide resistance in Candida albicans.

ABSTRACT: Candida albicans is usually a harmless human commensal. Because inflammatory responses are not normally induced by colonization, antimicrobial peptides are likely integral to first-line host defense against invasive candidiasis. Thus, C. albicans must have mechanisms to tolerate or circumvent molecular effectors of innate immunity and thereby colonize human tissues. Prior studies demonstrated that an antimicrobial peptide-resistant strain of C. albicans, 36082(R), is hypervirulent in animal models versus its susceptible counterpart (36082(S)). The current study aimed to identify a genetic basis for antimicrobial peptide resistance in C. albicans. Screening of a C. albicans genomic library identified SSD1 as capable of conferring peptide resistance to a susceptible surrogate, Saccharomyces

SUBMITTER: Gank KD 

PROVIDER: S-EPMC2519774 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature